Work

15d-PGJ2 is a new hope for controlling tumor growth.

Year: 2018

Type: review

Abstract: 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a natural PPARγ agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.

Source: PubMed

Authors: Qingli Bie, Haixin Dong, Chengqiang Jin, Hao Zhang, Bin Zhang

Institutions: Affiliated Hospital of Jining Medical University, Jining Medical University

Language: English

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2979969557

FWCI: 0.426

Cites: 98

Cited by: 36

Related to: 10