Work

Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells.

Year: 2017

Type: article

Abstract: androgen biosynthesis, with simvastatin being the most effective. Importantly, in combination treatments, statins specifically enhanced growth suppression with added effects by anti-androgen abiraterone acetate on the CR PCa cells. Thus, statins can be used in conjunction with abiraterone acetate to enhance anti-androgen therapy for CR PCa.

Source: PubMed

Authors: Dannah R Miller, Matthew A Ingersoll, Yu-Wei Chou, C Brent Wakefield, Yaping Tu, Fen-Fen Lin, William G Chaney, Ming-Fong Lin

Institutions: University of Nebraska Medical Center, Kaohsiung Chang Gung Memorial Hospital, Creighton University, Kaohsiung Medical University

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: MIC-1 and its functional partners in prostate cancer racial disparity, Signaling in Androgen-Refractory Prostate Cancer, Cancer Biology Training Program

OpenAlex ID: W2980058101

FWCI: 0.608

Cites: 43

Cited by: 8

Related to: 10