miR-1231 exacerbates arrhythmia by targeting calciumchannel gene CACNA2D2 in myocardial infarction.
Year: 2017
Type: article
Abstract: ameliorates arrhythmias in rat MI hearts; conversely, the forced overexpression of miR-1231 promotes arrhythmias. Furthermore, cacna2d2 knockdown alone induced arrhythmias in ischemic hearts, despite knockdown of miR-1231. Thus, these results indicate that miR-1231 exacerbates arrhythmia by inhibiting cacna2d2 in ischemic heart, which shed light on the important arrhythmogenic function of miR-1231 in MI and suggest it may serve as a potential antiarrhythmic target.
Source: PubMed
Authors: Jiefang Zhang, Lili Wu, Zhengwei Li, Guosheng Fu
Institutions: Sir Run Run Shaw Hospital, Zhejiang University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2980125214