Work

Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia

Year: 2019

Type: review

Abstract: The prevalence of obesity has steadily risen over the past decades, even doubling in more than 70 countries. High levels of body fat (adiposity) and obesity are associated with endocrine and hormonal dysregulation, cardiovascular compromise, hepatic dysfunction, pancreatitis, changes in drug metabolism and clearance, inflammation, and metabolic stress. It is thus unsurprising that obesity can affect the development of and survival from a wide variety of malignancies. This review focuses on acute lymphoblastic leukemia, the most common malignancy in children, to explore the multiple mechanisms connecting acute lymphoblastic leukemia, obesity, and adipocytes, and the implications for leukemia therapy.

Source: JNCI Monographs

DOI: 10.1093/jncimonographs/lgz020

Authors: Etan Orgel, Jessica L Sea, Steven D Mittelman

Institutions: University of Southern California, Children's Hospital Los Angeles, University of California, Los Angeles

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute