P2‐463: Development of an Upsa Short Form for Use in Longitudinal Studies in the Early Alzheimer's Disease Spectrum
Year: 2019
Type: article
Study design: Observational Study
Abstract: There has been increasing interest in the use of performance based measures of function as opposed to informant based measures, In part this is due to increased sensitivity and fewer ceiling effects in groups with only mild or very mild cognitive attenuation (i.e., so-called pre-clinical AD). We sought to determine if a performance based measure of everyday function would demonstrate adequate psychometric properties and validity in the context of serial assessment over a one year period in patients with Mild Cognitive Impairment (MCI) and early stage Alzheimer's disease (AD). Three groups of subjects participated in the study: a healthy older control group (HC=43), an MCI group (N=20), and an AD group (N=26). Participants were assessed with the performance based measure at baseline, six weeks, and one year, in a specialized center for the assessment and treatment of AD. A three subtest short form of the UPSA (called the UPSA 3) was the measure of interest. It consistent of the Communication, Planning, and Finance subtests. Mixed model repeated measures were used to assess performance over time. Large group effects were present (HC>MCI>AD). Additionally, the AD and MCI groups demonstrated declines over year, while the HC group remained stable (group x time interaction p= 0.11). The MCI/AD group demonstrated adequate test-retest reliability and did not demonstrate ceiling or floor effects. Our data indicate that the UPSA 3 is suitable for clinical trials in that has adequate ecological coverage, has reasonable, psychometric properties, and perhaps most importantly, demonstrates validity in serial assessments.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2980338533