Work

Collagen type V a2 (COL5A2) is decreased in steroid-induced necrosis of the femoral head.

Year: 2018

Type: article

Abstract: analyses revealed that post-MP treatment, rats showed typical signs of ONFH by micro-CT scanning and hematoxylin and eosin (H&E) staining. Immunohistochemical staining demonstrated that the expression of COL5A2 and vascular endothelial growth factor (VEGF) was significantly decreased post-MP treatment. In conclusion, the expression COL5A2 was lower in patients with steroid-induced ONFH, hence COL5A2 may be a promising therapeutic target for steroid induced ONFH treatment.

Source: Europe PMC (PubMed Central)

Authors: Fan Yang, Pengbo Luo, Hao Ding, Changqing Zhang, Zhenhong Zhu

Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital

Language: English

Topic: Bone and Joint Diseases

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980392554

FWCI: 2.143

Cites: 45

Cited by: 17

Related to: 10