Work

Vascularized and Innervated Skeletal Muscle Tissue Engineering

Year: 2019

Type: article

Abstract: Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201900626

Authors: Jordana Gilbert‐Honick, Warren Grayson

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Maryland Stem Cell Research Fund, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases