Work

Rapid Growth and Metabolism of Uropathogenic Escherichia coli in Relation to Urine Composition

Year: 2019

Type: review

Abstract: express transporters for peptides, amino acids, carbohydrates, and iron and genes associated with nitrogen limitation, amino acid synthesis, nucleotide synthesis, and nucleotide salvage. Mouse models confirm the requirement for many, but not all, of these genes. Laboratory evolution studies suggest that rapid nutrient uptake without metabolic rewiring is sufficient to account for rapid growth. Proteins and pathways required for rapid growth should be considered potential targets for alternate or adjunct therapies.

Source: Clinical Microbiology Reviews

DOI: 10.1128/cmr.00101-19

Authors: Larry Reitzer, Philippe Zimmern

Institutions: The University of Texas at Dallas, The University of Texas Southwestern Medical Center

Language: English

Topic: Escherichia coli research studies

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980400722

FWCI: 1.088

Cites: 122

Cited by: 82

Related to: 10