Work

Trends in the Use of Medications and Supplements to Treat or Prevent Dementia

Year: 2019

Type: article

Abstract: OBJECTIVE: To examine older adults' use over time of agents to treat or prevent dementia or enhance memory. DESIGN: Longitudinal community study with 10-year annual follow-up (2006-2017). SETTING: Population-based cohort. PARTICIPANTS: A total of 1982 individuals with a mean (SD) age of 77 (7.4) years at baseline. MEASUREMENTS: Demographics, self-report, direct inspection of prescription antidementia drugs and nonprescription supplements, cognitive and functional assessments, Clinical Dementia Rating (CDR®) Dementia Staging Instrument. RESULTS: Supplement use was reported by 27% to 42% of participants over 10 years. Use was associated with younger age, high school or greater education, good to excellent self-reported health, higher memory test scores, and absence of cognitive impairment or dementia (CDR=0). Over the same period, about 2% to 6% of participants took prescription dementia medications over 10 years. Use was associated with lower memory test scores, at least mild cognitive impairment (CDR≥0.5), fair to poor self-rated health, and high school or lesser education. CONCLUSIONS: The use of both prescription drugs and supplements increased over time, except for decreases in ginkgo and vitamin E. Prescription drug use appeared in line with prescribing guidelines. Supplement use was associated with higher education and better self-rated health; it persists despite a lack of supportive evidence.

Source: Alzheimer Disease & Associated Disorders

DOI: 10.1097/wad.0000000000000357

Authors: Gary P. Stoehr, Erin Jacobsen, Yichen Jia, Beth E. Snitz, Mary Ganguli

Institutions: D'Youville University, University of Pittsburgh

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging