Cigarette Smoke and DNA Cleavage Promote Lung Inflammation and Emphysema.
Year: 2017
Type: article
Abstract: activation of DNA repair enzymes, and histological studies provide evidence for DNA double-stranded breaks. Emphysematous lung myeloid dendritic cells that contain nCB express pro-inflammatory cytokines, and can efficiently differentiate naive CD4 T cells to interferon-g-secreting T helper 1 and interleukin 17A expressing cell subsets. Together these findings indicate that nCB accumulation in lung innate immune cells can initiate and sustain lung inflammation and promote emphysema development.
Source: Europe PMC (PubMed Central)
Authors: Farrah Kheradmand, R You, Bon Hee Gu, D B Corry
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2980494386