Work

Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis

Year: 2019

Type: article

Study design: Observational Study

Abstract: South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0223308

Authors: Tara C. Bouton, Margaretha de Vos, Elizabeth J. Ragan, Laura F. White, Leonie Van Zyl, Danie Theron, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson

Institutions: Brown University, Stellenbosch University, National Research Foundation, Boston University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,595

Funders: American Society of Tropical Medicine and Hygiene, National Institutes of Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL), Boston University Clinical and Translational Science Institute, Providence/Boston Center for AIDS Research (CFAR), HIV and Other Infectious Consequences of Substance Use

OpenAlex ID: W2980507267

FWCI: 0.766

Cites: 10

Cited by: 8

Related to: 10