Work

PAI-1 Inhibition - Another Therapeutic Option for Cardiovascular Protection.

Year: 2015

Type: article

Abstract: Current research suggest that plasminogen activator inhibitor type 1 (PAI-1) is an important contributor to a number of disease processes. The aim of the current paper is to emphasize the deleterious effects of PAI-1 on cardiovascular diseases development and progression. The plasminogen system is known by its role in hemostasis and thrombosis regulation. Lifestyle changes and pharmacological treatment can regulate PAI-1 levels and functions. Some pharmacologic agents currently used in the management of atherosclerosis and its complications can counteract the deleterious effects of PAI-1.

Source: PubMed Central

Authors: Monica Mariana Baluta, Marius Marcian Vintila

Institution: Carol Davila University of Medicine and Pharmacy

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980555994

FWCI: 0.942

Cites: 34

Cited by: 26

Related to: 10