Work

Under Elevated c-di-GMP in Escherichia coli, YcgR Alters Flagellar Motor Bias and Speed Sequentially, with Additional Negative Control of the Flagellar Regulon via the Adaptor Protein RssB

Year: 2019

Type: article

Abstract: Flagellum-driven motility has been studied in E. coli and Salmonella for nearly half a century. Over 60 genes control flagellar assembly and function. The expression of these genes is regulated at multiple levels in response to a variety of environmental signals. Cues that elevate c-di-GMP levels, however, inhibit motility by direct binding of the effector YcgR to the flagellar motor. In this study conducted mainly in E. coli , we show that YcgR is the only effector of motor control and tease out the order of YcgR-mediated events. In addition, we find that the σ S regulator protein RssB contributes to negative regulation of flagellar gene expression when c-di-GMP levels are elevated.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00578-19