Work

Autoimmune conditions and primary central nervous system lymphoma risk among older adults

Year: 2019

Type: article

Abstract: Primary central nervous system lymphoma (PCNSL) risk is highly increased in immunosuppressed individuals, such as those with human immunodeficiency virus infection and solid organ transplant recipients, but rates are increasing among immunocompetent older adults (age ≥65 years). We utilized data from a large, nationally-representative cohort of older adults in the United States and found that PCNSL is significantly associated with systemic lupus erythematosus, polyarteritis nodusa, autoimmune hepatitis, myasthenia gravis and uveitis. Immunosuppressive drugs given to treat these conditions may increase PCNSL risk, but these associations cannot explain the observed temporal increase in PCNSL rates, given the low prevalence of these conditions.

Source: British Journal of Haematology

DOI: 10.1111/bjh.16222

Authors: Parag Mahale, Megan M. Herr, Eric A. Engels, Ruth M. Pfeiffer, Meredith S. Shiels

Institutions: Division of Cancer Epidemiology and Genetics, Roswell Park Comprehensive Cancer Center

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,500