O2‐11‐01: Cross‐sectional Associations Between Csf Biomarkers of Amyloid and Tau With Neuropsychiatric Symptoms: the Mayo Clinic Study of Aging
Year: 2019
Type: article
Study design: Observational Study
Abstract: The association between cerebrospinal fluid (CSF) derived biomarkers of Alzheimer 's disease (AD) and behavioral measures remains unknown among older adults free of dementia. We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging, including persons free of dementia aged ≥ 50 years. We measured CSF amyloid (Aβ42), hyperphosphorylated Tau (p-tau) and total Tau (t-tau) using Elecsys® CSF electrochemiluminescence immunoassays platform (Roche Diagnostics). All participants also completed the Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI) and Neuropsychiatric Inventory Questionnaire (NPI-Q). We conducted linear and logistic regression analyses that were adjusted for age, sex, education, and APOE ε4 carrier status. CSF-derived variables were log-transformed; continuous BDI and BAI had 1 added and were also log-transformed. In all analyses, CSF biomarkers were treated as numeric predictors and NPS were considered as outcomes. The sample was comprised of 784 persons (699 cognitively unimpaired, CU and 85 with mild cognitive impairment, MCI). The mean [SD] age was 71.5 [9.9] years; 56.9% of participants were males; mean [SD] education was 14.6 [2.7] years; and 27% were APOE ε4 carriers. CSF-Aβ42 was associated with BDI (estimate −0.2445; p <0.001) and BAI scores (est. −0.2104; p < 0.01) in linear models. CSF-Aβ42 was also associated with clinical depression as indicated by BDI score ≥ 13 (Odds Ratio 0.508; p = 0.02), clinical anxiety as measured by BAI score ≥ 10 (OR 0.526; p = 0.03), as well as NPI-Q assessed presence of anxiety (OR 0.293; p < 0.001), apathy (OR 0.485; p = 0.04), and nighttime behavior (OR 0.460; p = 0.01) in logistic models. CSF-derived measures of p-tau and t-tau were not associated with neuropsychiatric symptoms. CSF amyloid beta but not tau was inversely associated with behavioral measures in community-dwelling older adults free of dementia, i.e. decreased CSF amyloid beta levels were associated with increased neuropsychiatric symptoms, albeit the effect sizes were small. This cross-sectional observation merits further investigation and needs to be confirmed by a prospective cohort study.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2980787791