Work

Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4+ T lymphocyte response.

Year: 2018

Type: article

Abstract: T cell subsets levels in recipients, reduce proinflammatory factor expression and increase anti-inflammatory cytokine expression. These findings indicate that some small-molecule inhibitors of p110 can serve as novel targets in acute allograft rejection treatment.

Source: Europe PMC (PubMed Central)

Authors: Chuanlei Yang, Xing Chen, Zhanjie Wei, Jie Xiao, Weiqiang Chen, Yuqiang Shang, Jinping Liu

Institutions: Wuhan Union Hospital, Central Hospital of Wuhan, Huazhong University of Science and Technology

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980800053

FWCI: 1.04

Cites: 48

Cited by: 7

Related to: 10