Work

Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker.

Year: 2018

Type: article

Abstract: by inactivating the mechanistic target of rapamycin complex 1 (mTORC1) and inducing autophagy and apoptotic cell death. This strong inhibition was dependent on the E3 ligase activity of RNF152. Ectopic expression of the RNF152-CS-mutant, which lacks E3 ligase activity, significantly restored the proliferation ability of CRC cells. Our findings showed that RNF152 inhibits colorectal cancer growth and may be a novel prognostic biomarker for the treatment of CRC.

Source: Europe PMC (PubMed Central)

Authors: Ximao Cui, Wenbin Shen, Guanghui Wang, Zhenyu Huang, Dongpeng Wen, Yili Yang, Yun Liu, Long Cui

Institutions: Shanghai Jiao Tong University, XinHua Hospital, Guizhou Provincial People's Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou Institute of Systems Medicine

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980859647

FWCI: 0.397

Cites: 26

Cited by: 11

Related to: 10