Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: Background: Data are limited regarding the association of cumulative burden and trajectory of body mass index (BMI) from early life with adult lipid disorders. Methods: The study cohort consisted of 5195 adults who had BMI repeatedly measured 4 to 21 times from childhood and had blood lipid measurements of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) and information on lipid-lowering medications in the last adult survey. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI. Results: Participants with dyslipidemia, high LDL-C, low HDL-C and high TG had consistently and significantly higher BMI levels from childhood to adulthood compared to those with normal lipid levels. After adjusting for age, race, sex, and cohort, increased risk of adult dyslipidemia was significantly associated with higher values of childhood BMI, adulthood BMI, total AUC and incremental AUC, with odds ratio (95% confidence interval) = 1.22 (1.15–1.29), 1.85 (1.74–1.97), 1.61 (1.52–1.71), and 1.59 (1.50–1.69), respectively, and p < 0.001 for all. The association patterns were similar in most race–sex subgroups. Conclusions: Adults with dyslipidemia versus normal lipid levels have consistently higher levels and distinct life-course trajectories of BMI, suggesting that the impact of excessive body weight on dyslipidemia originates in early life.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm8101725
Institutions: Tulane University, University of Turku, Turku University Hospital, Murdoch Children's Research Institute, Wake Forest University Health Sciences, Wake Forest University, University of Oxford, University of Minnesota, University of Iowa, University of Colorado Anschutz, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Cincinnati Medical Center, University of Tasmania, Menzies Institute for Medical Research
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,824
Funders: Roy J. Carver Charitable Trust, Foundation for Cardiovascular Research, Yrjö Jahnssonin Säätiö, European Commission, Kela, Academy of Finland, Suomen Kulttuurirahasto, Juho Vainion Säätiö, Signe ja Ane Gyllenbergin Säätiö, Emil Aaltosen Säätiö, Sydäntutkimussäätiö, Tampereen Tuberkuloosisäätiö, Diabetesliitto, Paavo Nurmen Säätiö, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Child Health and Human Development, National Center for Research Resources, H2020 European Research Council
Awards: G1037428335, G1242256790, G1335418636, Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-up, G1601895641, G1872575776, Ancestral environmental exposures and offspring health – a multigenerational epidemiologic cohort study across 3 generations, G1891033315, G2026946236, G2230772921, G2330237237, Childhood Growth, Biological Aging and Midlife Cardio-Metabolic Outcomes, G2513778610, G2740112086, A multidisciplinary approach for the stratification of patients with carotid artery disease, G3111916513, G3213590351, G3289800213, G33539551, G3858258543, G4139205196, G4220408732, G427637532, G4321089066, G4351223834, G4655867613, G4917507785, G4965406020, G4989131299, G5090981026, G5208171454, G5212302835, G5474452856, G5678199996, G5770909501, G6164432047, G6355767702, G6682689995, G6802942620, Evolution of Cardiovascular Risk with Normal Aging, Louisiana Clinical and Translational Science Center, G992154238
OpenAlex ID: W2980872069