Differential Expression of Immune Checkpoint Molecules on CD8+T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes
Year: 2019
Type: article
Abstract: Without an effective means of eliminating HSV-1 from latently infected neurons, efforts to control the virus have centered on preventing viral reactivation from latency. Virus-specific CD8+T cells within the infected TG have been shown to play a crucial role in inhibiting viral reactivation, and with a portion of these cells exhibiting functional impairment, checkpoint molecule immunotherapies have presented a potential solution to enhancing the antiviral response of these cells. In pursuing this potential treatment strategy, we found that Tim-3 (often associated with CD8+T cell functional exhaustion) is not upregulated on impaired cells but instead is upregulated on highly functional cells that have recently received antigenic stimulation. These findings support a role for Tim-3 as a marker of activation rather than exhaustion in this model, and we provide additional evidence for the hypothesis that there is persistent viral gene expression in the HSV-1 latently infected TG.
Source: Journal of Virology
DOI: 10.1128/jvi.01132-19
Institution: University of Pittsburgh
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1220188177, G138377103, G1970662503, G2719075989, G3212146654, G380003883, G3971487397, G4554005177, G5765630191, Viral Persistence and Pathogenesis, G9000004072, G9000019426, G9000020868, G9000030729, G9000106115, G9000130511, G9000279717, G9000299866, Core Grant for Vision Research, Contribution of sympathetic nerves to herpes stromal keratitis
OpenAlex ID: W2980894837