Year: 2019
Type: article
Abstract: Lyme disease, caused by some Borrelia burgdorferi sensu lato, is the most common tick-borne illness in the Northern Hemisphere and the number of cases, and geographic spread, continue to grow. Previously identified B. burgdorferi proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infection in the host. Discovery of the mechanism of action of the first vaccine catalyzed the development of new strategies to control Lyme disease that bypassed direct vaccination of the human host. Thus, novel prevention concepts center on proteins produced by B. burgdorferi during tick transit and on tick proteins that mediate feeding and pathogen transmission. A burgeoning area of research is tick immunity as it can unlock mechanistic pathways that could be targeted for disruption. Studies that shed light on the mammalian immune pathways engaged during tick-transmitted B. burgdorferi infection would further development of vaccination strategies against Lyme disease.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciz872
Authors: Maria Gomes-Solecki, Paul M Arnaboldi, P Bryon Backenson, Jorge L Benach, Christopher L Cooper, Raymond J Dattwyler, Maria Diuk-Wasser, Erol Fikrig, J W Hovius, Will Laegreid, Urban Lundberg, Richard T Marconi, Adriana R Marques, Philip Molloy, Sukanya Narasimhan, Utpal Pal, Joao H F Pedra, Stanley Plotkin, Daniel L Rock, Patricia Rosa, Sam R Telford, Jean Tsao, X Frank Yang, Steven E Schutzer
Institutions: University of Tennessee Health Science Center, New York Medical College, New York State Department of Health, Stony Brook University, United States Army Medical Research Institute of Infectious Diseases, Columbia University, Yale University, Amsterdam UMC Location University of Amsterdam, Amsterdam University Medical Centers, University of Wyoming, Valneva (Austria), Virginia Commonwealth University Medical Center, National Institutes of Health, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park, University of Pennsylvania, University of Illinois Urbana-Champaign, Tufts University, Michigan State University, Indiana University School of Medicine, Rutgers New Jersey Medical School
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Funders: U.S. Department of Health and Human Services, New York State Department of Health, Zoetis, Global Lyme Alliance, Steven and Alexandra Cohen Foundation, European Commission, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G1044130170, G1854786348, Field trial and modeling of transmission blocking vaccine to prevent Lyme disease, G2686697970, G3930536406, G5606609238, G6201572492, G653261131, G7521418551, G8155190080, Tick Saliva and Pathogen Transmission, Yale Clinical and Translational Science Award, Regulatory Network of the Lyme Disease Pathogen
OpenAlex ID: W2980901856