Work

Aptamers and apple pies: a mini-review of PSMA aptamers and lessons from Donald S. Coffey.

Year: 2018

Type: review

Abstract: transcription and polyacrylamide gel purification, while smaller isoforms can be generated by chemically synthesis. A series of aptamer conjugates have been developed through chemical crosslinking, complementary annealing strategies, or a combination of both, for the targeting of experimental therapeutics to and into prostate cancer cells. The resulting aptamer conjugates, including nanoparticles and siRNA conjugates, selectively target PSMA-positive prostate cancer cells and xenograft tumors, and demonstrate potent cytotoxic and tumoricidal activity. These experimental therapeutic agents provide a platform for realizing and optimizing the potential of tumor-selective targeting and drug delivery.

Source: Europe PMC (PubMed Central)

Author: Shawn E Lupold

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980955228

FWCI: 0.132

Cites: 42

Cited by: 15

Related to: 10