Work

Alternative role of noncoding RNAs: coding and noncoding properties

Year: 2019

Type: article

Abstract: Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific "switch" triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.

Source: Journal of Zhejiang University SCIENCE B

DOI: 10.1631/jzus.b1900336

Authors: Gui-zhen Zheng, Wei Li, Zhi-yong Liu

Institutions: Tongji University, Shanghai East Hospital, Second Military Medical University, Shanghai Changzheng Hospital, Kunming General Hospital of Chengdu Military Command, Changhai Hospital

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2980955759

FWCI: 0.082

Cites: 56

Cited by: 6

Related to: 10