Work

HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma.

Year: 2019

Type: article

Abstract: cell line studies demonstrated that silencing HSF2 expression could decrease the proliferation in HCC cells. In depth mechanism analysis demonstrated that HSF2 promoted cell proliferation via positive regulation of aerobic glycolysis, and HSF2 interacted with euchromatic histone lysine methyltransferase 2 (EHMT2) to epigenetically silence fructose-bisphosphatase 1 (FBP1), which is a tumor suppressor and negative regulator of aerobic glycolysis in HCC. HSF2 expression indicated unfavorable prognosis of HCC patients and it could regulate aerobic glycolysis by suppression of FBP1 to support uncontrolled proliferation of HCC cells.

Source: PubMed

Authors: Li-Na Yang, Zhou-Yu Ning, Lai Wang, Xia Yan, Zhi-Qiang Meng

Institutions: Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Fudan University

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980972006

FWCI: 1.43

Cites: 42

Cited by: 30

Related to: 10