Work

The metabolic modulator PGC-1α in cancer.

Year: 2019

Type: article

Abstract: The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles have shown that PGC-1α expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review.

Source: Europe PMC (PubMed Central)

Authors: Frederic Bost, Lisa Kaminski

Institutions: Inserm, Centre Méditerranéen de Médecine Moléculaire

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2980989560

FWCI: 6.097

Cites: 118

Cited by: 119

Related to: 10