O4‐13‐02: Mid‐ and Late‐life Physical Activity and Brain Amyloid Deposition: the Atherosclerosis Risk in Communities (aric)‐pet Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: Physical activity (PA) may slow the progression of dementia through several pathways, including those that limit brain amyloid deposition. We assessed the association of mid- and late-life PA with late-life brain amyloid deposition among 326 non-demented men and women in a bi-racial community-based cohort. Using an interviewer-administered PA questionnaire at cohort exams 1 (1987-1989) and 5 (2011-2013), past year leisure-time PA was estimated in metabolic equivalent (MET)-minutes/week. Participants’ PA levels were also classified as (1) PA participation (yes/no) and (2) into one of four distribution-based categories (none, low, middle, or high PA) at each exam. A brain MRI with Florbetapir PET was performed at exam 5. A median cutoff SUVR value >1.2 indicated elevated brain amyloid deposition. Prevalence odds ratios (OR) of elevated brain amyloid deposition compared to no elevated brain amyloid deposition were estimated (1) according to participation in PA and (2) across continuous values and distribution-based categories of PA, adjusted for age, sex, education, ApoE4, and race-center. At the ARIC-PET exam, mean age was 76 years; 42% were male, 41% Black, and 52% had elevated brain amyloid deposition. A total of 200 (61%) and 224 (69%) participants reported participation in leisure-time PA at exams 1 and 5, respectively. The age-adjusted proportion of elevated amyloid deposition among participants reporting none, low, middle, or high PA at visit 5 was 54%, 61%, 48%, and 42%, respectively. In mid-life (exam 1), participation in PA was associated with a lower odds of elevated late-life amyloid deposition (OR=0.59, 95% confidence interval (CI): 0.37-0.95) although no differences were observed across levels of PA. In late-life (exam 5), a 1 standard deviation (970 MET-min/week) higher level of PA was associated with a 28% (OR= 0.72, 95% CI: 0.52-0.99) lower odds of elevated amyloid deposition. The associations were attenuated and non-significant in models adjusted for vascular risk factors. No evidence of heterogeneity by race, sex, ApoE4, or cognitive status (normal vs. MCI) was observed.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2980990489