Work

Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin

Year: 2017

Type: report

Abstract: Key MessagesPurpose of Review Assess comparative effectiveness and safety of treatments for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Key Messages• Comparative evidence on treatment of BCC and SCC is limited.Many comparisons were evaluated in one or two randomized controlled trials only.• Surgery and radiotherapy have lower recurrence rates for BCC than interventions that destroy lesions with heat or cold, photodynamic therapy (PDT), or curettage.• There is moderate confidence that PDT for BCC is associated with better cosmetic outcomes than surgery.• Serious adverse events, events leading to treatment discontinuation, and treatment site infections were uncommon with all treatments for BCC.• Recurrence rates for SCC in situ were lower with PDT and cryotherapy than with drugs.Evidence was insufficient to draw conclusions for other treatments.ii This report is based on research conducted by the Brown Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00002-I).The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ.Therefore, no statement in this report should be construed as an official position of AHRQ or of the

DOI: 10.23970/ahrqepccer199