Work

Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis

Year: 2020

Type: article

Abstract: (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.

Source: eLife

DOI: 10.7554/elife.52551

Authors: Haaris S Khan, Vidhya R Nair, Cody R Ruhl, Samuel Alvarez-Arguedas, Jorge L Galvan Rendiz, Luis H Franco, Linzhang Huang, Philip W Shaul, Jiwoong Kim, Yang Xie, Ron B Mitchell, Michael U Shiloh

Institutions: The University of Texas Southwestern Medical Center, Universidade Federal de Minas Gerais, Harold C. Simmons Comprehensive Cancer Center

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Burroughs Wellcome Fund, Welch Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: G1277860013, G1517718930, G236389114, G267413303, G5520316217, G5559644901, Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents, G7186876465, Human airway microfold cells in mucosal immunity to bacterial pathogens, Dichotomous Role of Endothelial SR-BI in Atherosclerosis, G8583101034, Integrative Immunology Training Grant, G9000273223

OpenAlex ID: W3009679013

FWCI: 0.54

Cites: 75

Cited by: 34

Related to: 10