P3‐548: Progression From Mild Cognitive Impairment to Alzheimer's Disease in Cancer Survivors
Year: 2019
Type: article
Abstract: Some studies have suggested having had cancer results in a decreased risk of developing Alzheimer's disease (AD) and vice versa. However, adverse effects of cancer and its treatments, especially in later-life, may result in cognitive decline similar to that in AD. Little is known about how previous cancer exposure can affect progression of AD. We utilized data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to evaluate progression to AD by self-reported cancer history. Progression from mild cognitive impairment (MCI) to AD was examined based on consensus clinical diagnoses using Cox proportional hazards regression. Among 578 participants, cancer survivors were older than those without history of cancer (75.95 vs. 72.94 years, p-value: <0.0001) and more likely to be White (p-value: 0.0160). There were no differences in education, baseline cognition based on ADAS-Cog scores, APOE e4 status, sex, marital status, or ethnicity between cancer survivors and others. Cox regression models indicated that cancer survivors had a significant decreased hazard of progression from MCI to AD (HR: 0.73, 95% CI: 0.56-0.96). We noted similar risk after adjustment for age, education, APOE e4 status, and baseline ADAS-Cog score (HR: 0.70, 95% CI: 0.53, 0.93). Cancer survivors showed evidence of decreased hazard of progression from MCI to AD, and is consistent with studies indicating previous cancer exposure is associated with decreased incidence of AD. Modeling covariates did not change the association. This analysis provides information on progression of AD based on cancer exposure and underscores the complex relationship between cancer and AD. A limitation to this observation is that the ADNI study recruited participants who were healthy enough for long-term follow-up. This limits the type and severity of previous cancers in participants. Further investigation is warranted in a dataset poised to stratify by specific cancer types and treatments and where all types of cancer of varying severity are included.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2981151362