Work

[Application of immunophenotypic analysis and molecular genetics in the diagnosis of acute promyelocytic leukemia].

Year: 2019

Type: article

Abstract: FCM could rapidly and effectively diagnose APL. Despite the fact that complex karyotypes with various additional chromosomal abnormalities were detected in approximately one third of APL cases in addition to the pathognomonic t (15;17) (q22;q21) , they had no observable impact on the overall immunophenotype. Molecular and genetic criteria were the golden criteria for the diagnosis of APL. About 10% of immunophenotyping cases relied on molecular genetics for diagnosis.

Source: PubMed Central

DOI: 10.3760/cma.j.issn.0253-2727.2019.04.005

Authors: J Y Gong, Y Y Li, C W Li, Y S Wang, Y Liu, C Wang, K Ru, Y C Mi, J X Wang, H J Wang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981239079

FWCI: 0.165

Cites: 25

Cited by: 3

Related to: 10