Work

Comparison of cachectic and non-cachectic sarcoma patients reveals an important role of Notch signaling in metastasis and myogenesis.

Year: 2019

Type: article

Study design: Observational Study

Abstract: and Notch pathway expression in MDSCs. Our findings suggest that there is no difference in inflammatory profile between cachexia and non-cachexia sarcoma samples. However, Cachectic sarcoma samples express increased Notch that mediates muscle wasting possibly through inhibition of myogenesis.

Source: PubMed Central

Authors: Feiqi Lu, David Osei-Hwedieh, Jonathan B Mandell, Alejandro Morales-Restrepo, Margaret L Hankins, Jared A Crasto, Ruichen Ma, Vu Dinh, Rebecca J Watters, Kurt R Weiss

Institutions: University of Pittsburgh, Tsinghua University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: Exploring the Mechanisms of Sarcoma-Associated Cachexia, Exploring Sarcoma Metastatic Potential, Cancer Center Support Grant

OpenAlex ID: W2981244795

FWCI: 0.248

Cites: 25

Cited by: 5

Related to: 10