P1‐367: Comparison of Ioflupane‐spect Findings Using Datquant in Patients With Alzheimer's Disease Dementia and Dementia With Lewy Bodies
Year: 2019
Type: article
Study design: Observational Study
Abstract: Reduced striatonigral uptake on ioflupane-SPECT reflects dopamine deficiency, and this finding is typical of dementia with Lewy bodies (DLB) using classic mean putamen to occipital ratio quantitation. This method relies on manual drawing of regions of interest, which introduces variability. Quantitative methods using computerized algorithms are increasingly being used. In this report, we compare ioflupane-SPECT findings between patients with DLB and Alzheimer's disease dementia (ADem) using z-scores from DaTQUANT software (GE Healthcare). The mean DaTQUANT z-scores of the caudate and putamen for each patient with DLB and ADem in the Mayo Alzheimer's Disease Research Center who had undergone ioflupane-SPECT were analyzed and compared. Data on those who had undergone autopsy were also analyzed. Data on 58 patients (mean age 67 ± 9.9 years, 45 male) were analyzed, of whom 40 had DLB and 18 had ADem (Figure). DLB had lower z-scores than ADem. Mean z-scores for each disorder were putamen: −1.99 ± 1.28 and caudate: −2.40 ± 1.41 for DLB; putamen: 0.52 ± 1.70 and caudate: 0.84 ± 1.90 for ADem (putamen P<0.001, caudate P<0.001). Among those with autopsy [N=19; 12 with Lewy body disease (LBD) pathology, 5 with Alzheimer's disease (AD) pathology and 2 with mixed LBD/AD pathology], the mean z-score for the LBD +/- AD pathology group was putamen: −3.06 ± 1.59 and caudate: −2.78 ± 1.47, while the AD only pathology group had mean z-scores as follows - putamen: 0.67 ± 0.71 and caudate 0.44 ± 0.20 (putamen P<0.001, caudate P <0.001).
Source: Alzheimer s & Dementia
Authors: Toji Miyagawa, Scott A. Przybelski, Daniela D. Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G. Lesnick, Jonathan Graff-Radford, David T. Jones, Rodolfo Savica, Daniel A. Drubach, David S. Knopman, Ronald C. Petersen, Julie A. Fields, Mary M. Machulda, Leah K. Forsberg, Laura A. Allen, Zuzana Nedelska, Joseph E. Parisi, Melissa E. Murray, Dennis W. Dickson, Bradley F. Boeve, Kejal Kantarci, Val J. Lowe
Institutions: Mayo Clinic, Mayo Clinic in Florida
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2981249888