Year: 2019
Type: article
Abstract: Prior work suggests that dementia incidence rates may be declining in western nations. However, data regarding temporal trends in amnestic mild cognitive impairment (aMCI) incidence are limited. The Einstein Aging Study (EAS) provided the opportunity to examine whether age specific aMCI incidence rates have declined over sequential birth cohorts from 1915 to 1935, and whether trends in aMCI rates have differed for white and black older adults. Age specific incidence of aMCI was examined by birth year for 1,233 individuals age ≥70 who were enrolled in EAS population based cohort between November 1, 1993 and February 22, 2016, did not have cognitive impairment at the time of enrollment and who had at least one annual follow-up clinic visit. aMCI was defined using the updated Petersen criteria as presence of objective memory impairment, subjective memory impairment, and absence of functional decline or clinical dementia. Poisson regression was used to model aMCI incidence as a function of age, sex, race, education and birth year. Profile likelihood was used to identify the timing of noticeable increases or drops in incidence rates, with a change point allowed to fall any time between 1915 and 1935. Additional models were adjusted for trends in self-reported history of diabetes, myocardial infarction and stroke. Analyses included 5,320.9 person years of follow-up. Poisson regression analyses did not yield any significant change point in aMCI incidence rates in the overall cohort (p-value for Likelihood ratio test controlling for age, sex, race/ethnicity and education = 0.76). This result was similar for Blacks and Whites, and among men or women born between 1915 and 1935. Although stroke history was an independent predictor of incident aMCI, inclusion of stroke, MI and diabetes in the models did not change the results
Source: Alzheimer s & Dementia
Institution: Albert Einstein College of Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2981286378