miR-429 mediates tumor growth and metastasis in colorectal cancer.

Year: 2017

Type: article

Abstract: Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.

Source: Europe PMC (PubMed Central)

Authors: Yantao Han, Qian Zhao, Jie Zhou, Rui Shi

Institutions: Qingdao University, Affiliated Hospital of Qingdao University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981381515

FWCI: 2.22

Cites: 45

Cited by: 37

Related to: 10