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Cover Feature: Synthesis and Anticancer Activity of Structure Simplified Naturally Inspired Dimeric Chromenone Derivatives (Eur. J. Org. Chem. 41/2019)

Year: 2019

Type: article

Abstract: The Cover Feature shows phomo-xanthone A, a naturally occurring secondary metabolite with promising anticancer activity that can be isolated from the Phomopsis fungus. Several phomoxanthone A-inspired structure simplified dimeric chromenones, with promising anticancer activity are also depicted. The structure simplified dimers are readily accessible by chemical synthesis and may serve as useful lead compounds for drug discovery and cancer research. The fungus graphic used in the petri dish is from: Rodrigo Pedrozo and Christopher R. Little, Department of Plant Pathology, Kansas State University [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0). More information can be found in the Full Paper by A. Mattson et al.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201901544

Authors: Rameez Ali, Yong Guan, Alexandria N. Leveille, Elizabeth Vaughn, Sangram Parelkar, Paul R. Thompson, Anita E. Mattson

Institutions: Worcester Polytechnic Institute, Appalachian State University, University of Massachusetts Chan Medical School

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,500

OpenAlex ID: W2981382953

FWCI:

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