Work

Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.

Year: 2019

Type: review

Abstract: Amyloid beta (Aβ) peptides have been implicated in both Alzheimer's disease (AD) and glaucoma and have been shown to be the key etiological factor in these dangerous health complications. On the other hand, it is well known that Aβ peptide can be generated from its precursor protein and massively released from the blood to nearby tissue upon the activation of platelets due to their involvement in innate immunity and inflammation processes. Here we review evidence about the development of AD and glaucoma neuronal damage showing their dependence on platelet count and activation. The correlation between the effect on platelet count and the effectiveness of anti-AD and anti-glaucoma therapies suggest that platelets may be an important player in these diseases.

Source: PubMed

DOI: 10.14670/hh-18-111

Authors: Mikhail Inyushin, Astrid Zayas-Santiago, Legier Rojas, Yuri Kucheryavykh, Lilia Kucheryavykh

Institution: Central University of the Caribbean

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences