Work

Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat.

Year: 2016

Type: article

Abstract: OBJECTIVE: This study aim to investigate whether early mitochondrial administration would be effective and whether high-dose mitochondria (15000 μg/rat) would be more effective than low-dose mitochondria (1500 μg/rat) for attenuating the monocrotaline (MCT/65 mg/kg/rat)-induced pulmonary artery hypertension (PAH) in rat. METHOD AND RESULTS: in all groups (all P<0.001). CONCLUSION: Low dose is superior to high dose of mitochondria for protecting against MCT-induced PAH. The paradoxical beneficial effect may imply therapy with 15000 μg/rat mitochondria is overdose in this situation.

Source: PubMed

Authors: Tien-Hung Huang, Sheng-Ying Chung, Sarah Chua, Han-Tan Chai, Jiunn-Jye Sheu, Yi-Ling Chen, Chih-Hung Chen, Hsueh-Wen Chang, Meng-Shen Tong, Pei-Hsun Sung, Cheuk-Kwan Sun, Hung-I Lu, Hon-Kan Yip

Institutions: Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, National Sun Yat-sen University, E-Da Hospital, I-Shou University, China Medical University, China Medical University Hospital

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981496531

FWCI: 1.473

Cites: 26

Cited by: 17

Related to: 10