Work

Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development

Year: 2019

Type: review

Abstract: Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we discuss how detailed structural knowledge of the interactions between OVs and their natural receptors provide valuable insights into tumor specificity of some viruses and re-targeting of alternate receptors for broad tumor tropism or improved tumor selectivity.

Source: Oncolytic Virotherapy

DOI: 10.2147/ov.s218494

Authors: Nadishka Jayawardena, Laura N Burga, John T Poirier, Mihnea Bostina

Institutions: University of Otago, NYU Langone Health, NYU Langone’s Laura and Isaac Perlmutter Cancer Center

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2981530099

FWCI: 0.85

Cites: 263

Cited by: 45

Related to: 10