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CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Year: 2019
Type: review
Abstract: Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, there has been a shift in the field to study CAF subpopulations and the emergent functions of these subsets in tumourigenesis. In this review, we explore how different aspects of CAF heterogeneity are defined and how these manifest in multiple cancers, with a focus on pancreatic ductal adenocarcinoma (PDAC). We also discuss therapeutic approaches to selectively target protumourigenic CAF functions, while avoiding normal fibroblasts, providing insight into the future of stromal targeting for the treatment of PDAC and other solid tumours.
DOI: 10.1016/j.trecan.2019.09.010
Authors: Brooke A. Pereira, Claire Vennin, Michael Papanicolaou, Cecilia R. Chambers, David Herrmann, Jennifer P. Morton, Thomas R. Cox, Paul Timpson
Institutions: Garvan Institute of Medical Research, UNSW Sydney, The Kinghorn Cancer Centre, The Netherlands Cancer Institute, University of Technology Sydney, Cancer Research UK Scotland Institute, University of Glasgow
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Centre of Excellence for Environmental Decisions, Australian Research Council, Cancer Research UK, National Breast Cancer Foundation, Cancer Institute NSW, Garvan Institute of Medical Research, National Health and Medical Research Council, Cancer Council NSW
OpenAlex ID: W2981546796
FWCI: 4.474
Cites: 137
Cited by: 324
Related to: 10