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Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes.

Year: 2017

Type: article

Abstract: BACKGROUND: and FTO gene polymorphisms in T2D was investigated. METHODS: One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study. The subjects were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS-PCR) and their clinical traits were analyzed. RESULTS: rs1052700 polymorphism and T2D, and between the FTO rs3751812 polymorphism and obesity (P = 0.03 and 0.003, respectively); however, no significant relationship was found between rs3751812 and T2D. CONCLUSION: rs1052700 polymorphism is related to T2D but not obesity.

Source: Europe PMC (PubMed Central)

Authors: Ramin Saravani, Hamid Reza Galavi, Nafiseh Noorzehi, Nasrin Ranjbar, Fatemeh Mollashahee-Kohkan

Institutions: Zahedan University of Medical Sciences, Zabol University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981548695

FWCI: 0.155

Cites: 27

Cited by: 7

Related to: 10