Prenatal Exposure to organophosphate and pyrethroid pesticides and birth outcomes in two urban cohorts of Pregnant Women
Year: 2019
Type: article
Study design: Observational Study
Abstract: TPS 742: Adverse birth outcomes 1, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Background/aim: pyrethroids and organophosphate pesticides are used to protect crops and reduce the transmission of insect-borne diseases. Previous studies have found an inverse association between exposure to these pesticides and birth outcomes. We aimed to investigate the effect of five urinary metabolites of pyrethroid and organophosphates among healthy pregnant women aged 16-35 living in New York City on the birth outcomes of their children. Methods: urinary biomarkers of 273 women from two cohorts of a) thyroid disruption and infant development (tdid) and b) sibling/hermanos cohort (s/h) were measured. We imputed the <lod values of the metabolites and missing values of the outcomes and covariates using log-probit regression method and multiple imputation methods, respectively. Linear regression models were used to evaluate the association between the ln-adjusted pesticide concentration and birth length, birthweight and head circumference. The association was assessed in multivariable linear regression models adjusting for season of birth, delivery mode, ethnicity, home ownership, marital status, education, income, employment, gestational age, maternal age and pre-pregnancy bmi separately for each cohort. Results: in tdid cohort, among boys, for each log unit increase in cpm (urinary metabolite of chlorpyrifos) in maternal urine, there was a 1.30 cm decrease in head circumference (95%ci: -2.41, -0.19). There was a positive association between urinary concentration of 2,4-dichlorophenoxyacetic acid and birthweight(grams) (b=99.7, 95%ci: 5.83, 193.57) in boys. Among girls, for each log unit increase in urinary level of opm (urinary metabolite of permethrin), there was a 0.70 cm increase in head circumference (95%ci: 0.13, 1.27). in s/h cohort we only found a positive association between urinary level of opm and birthweight(grams) (b=183.99, 95%ci: 14.08, 353.9) among boys. Conclusions: chlorpyrifos metabolites appeared to inversely affect the head circumference of the boys while permethrin metabolites appeared to increase the head circumference among girls.
Source: Environmental Epidemiology
Authors: Balalian A, Liu X, Whyatt R, Herbstman J, Daniels S, Factor-Litvak P
Institutions: Columbia University, Ben-Gurion University of the Negev
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,200
OpenAlex ID: W2981569272