Work

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Year: 2019

Type: article

Abstract: Natriuretic peptides (NPs) are cardiac derived hormones that are secreted in response to increased wall stress, stretching of the myocardium, volume overload, and angiotensin II stimulation. The principal circulating NPs, atrial and B-type NP (ANP and BNP respectively) are released as precursor molecules (proANP and proBNP) which are processed to active components ANP and BNP, and inactive amino-terminal fragments NT-proANP and NT-proBNP (1).

Source: Annals of Translational Medicine

DOI: 10.21037/atm.2019.10.59

Authors: Vibhu Parcha, Pankaj Arora

Institutions: University of Alabama at Birmingham, UAB Medicine, Birmingham VA Medical Center

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute