Predictors of cord blood concentrations of perfluoroalkyl and polyfluoroalkyl substances from a Chinese birth cohort
Year: 2019
Type: conference-abstract
Abstract: OPS 19: Chemicals: exposure assessment challenges, Room 110, Floor 1, August 28, 2019, 1:30 PM - 3:00 PM Some epidemiological studies have suggested that exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) during pregnancy may affect reproductive outcomes. Most of the studies focused on maternal blood PFAS levels, while fewer studies evaluating levels in umbilical cord serum. Our study aimed to evaluate socio-demographic, lifestyle, and dietary factors as the predictors of PFASs concentrations in cord blood. Umbilical cord blood samples and information on socio-demographic, lifestyle, and dietary habits were collected from 337 pregnant women during November 2013 to December 2015 in Zhoukou City, China. 11 kinds of PFASs were analyzed by liquid chromatography-mass spectrometry. Regression analysis were conducted to assess the associations of serum PFASs with socio-demographic, lifestyle, and dietary factors. Seven PFASs, including including perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), and perfluorododecanoic acid (PFDoA), were detected in > 75% of the cord blood samples. PFOA and PFOS were the largest contributors to PFAS levels in cord blood, and the medical concentrations was 1.25 ng/mL and 1.00 ng/mL respectively. The mothers who were older, primiparous had higher PFAS concentrations. Higher intake of eggplant, pickles, beef, sweet potato, garlic, rice was associated with higher PFAS concentrations. Whereas intake of milk, green leafy vegetables, and green leafy vegetables during pregnancy were contributed to the lower PFAS concentrations. Our results have suggested that age, parity, some dietary factors as the determinants of exposure to PFASs should be considered in exposure assessment
Source: Environmental Epidemiology
Institutions: Hubei Provincial Center for Disease Control and Prevention, Wuhan Institute of Technology, Chinese Center For Disease Control and Prevention, National Institute for Occupational Health and Poison Control, Henan Provincial Center for Disease Control and Prevention, Fred Hutch Cancer Center
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,200
OpenAlex ID: W2981702224