Work

BiP: Master Regulator of the Unfolded Protein Response and Crucial Factor in Flavivirus Biology .

Year: 2017

Type: article

Abstract: Flaviviruses have an intimate relationship with their host cells, utilizing host proteins during replication. Much of viral genome replication and virion assembly occurs on and within the endoplasmic reticulum (ER). As a cellular protein folding hub, the ER provides an ideal environment for flaviviruses to replicate. Flaviviruses can interact with several ER processes, including the unfolded protein response (UPR), a cellular stress mechanism responsible for managing unfolded protein accumulation and ER stress. The UPR can alter the ER environment in several ways, including increasing ER volume and quantity of available chaperones, both of which can favor viral replication. BiP, a chaperone and master regulator of the UPR, has been demonstrated to play a key role in several flavivirus infections. Here we describe what is known in regard to BiP, its implicated role with flavivirus infection, and what remains to be discovered.

Source: Europe PMC (PubMed Central)

Authors: Tyler G Lewy, Jeffrey M Grabowski, Marshall E Bloom

Institutions: National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981725650

FWCI: 3.537

Cites: 64

Cited by: 75

Related to: 10