Work

Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation

Year: 2019

Type: article

Abstract: knockout mice, and inducible expression of NEUROD2 caused TET2-associated demethylation at its in vivo binding sites. The data suggest that the reorganization of DNA methylation in developing neurons involves NEUROD2 and TET2-mediated DNA demethylation.

Source: Science Advances

DOI: 10.1126/sciadv.aax0080

Authors: Maria A. Hahn, Seung-Gi Jin, Arthur X. Li, Jiancheng Liu, Zhijun Huang, Xiwei Wu, Byung-Wook Kim, Jennifer Johnson, Adrienne-Denise V. Bilbao, Shu Tao, Jacob A. Yim, Yuman Fong, Sandra Goebbels, Markus H. Schwab, Qiang Lu, Gerd P. Pfeifer

Institutions: City Of Hope National Medical Center, City of Hope, Van Andel Institute, Max Planck Institute of Experimental Medicine, Medizinische Hochschule Hannover

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Institute of Mental Health, National Cancer Institute

Awards: Epigenomic Modifications in Mammalian Neurogenesis, G4561921799, 5-hydroxymethylcytosine in human cancer, G8205570726, Cancer Center Support Grant

OpenAlex ID: W2981796752

FWCI: 1.639

Cites: 68

Cited by: 45

Related to: 10