Wettability Engendered Templated Self-Assembly (WETS) for the Fabrication of Biocompatible, Polymer–Polyelectrolyte Janus Particles
Year: 2019
Type: article
Abstract: Fabrication of charged, multiphasic, polymeric micro- and nanoparticles with precise control over their composition, size, and shape is critical for developing the next generation of drug carriers for combinatorial therapies and theranostics. The addition of charged polyelectrolyte multilayers on the surface of polymeric particles can significantly improve their stability, targeting efficacy, drug-release kinetics, and their ability to encapsulate different drugs within a single particle. Many of the traditional methods for multilayer functionalization of multiphasic polymeric particles are time and energy intensive which significantly limits their scalability, and therefore therapeutic potential. In this work, we combine the bulk layer-by-layer polyelectrolyte application methodology with our previously developed technique of fabricating multiphasic polymeric particles on substrates with patterned wettability to synthesize biocompatible, monodisperse, Janus polymer-polyelectrolyte particles.
Source: ACS Macro Letters
Authors: Sai P. R. Kobaku, Catherine S. Snyder, Raghuraman G. Karunakaran, Gibum Kwon, Philip Wong, Anish Tuteja, Geeta Mehta
Institution: University of Michigan
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: G2727073112, Identification of Distinctly Expressed Genes and Altered Metabolic Pathways in a Physiologically Relevant 3D Spheroid Model of Ovarian Cancers, High-Throughput Platform for Patient-Derived, Small Cell Number, Three-Dimensional Ovarian Cancer Spheroids, G5134583712, University of Michigan Rogel Cancer Center Support Grant 2023-2028, G955900205
OpenAlex ID: W2981857036