Work

LncRNA SNHG5 regulates imatinib resistance in chronic myeloid leukemia via acting as a CeRNA against MiR-205-5p.

Year: 2017

Type: article

Abstract: functional assay showed that overexpression of SNHG5 in K562 cells increased imatinib resistance and knock-down of SNHG5 reduced the imatinib resistance in K562-R cells. Further experiments showed that SNHG5 promotes imatinib resistance through regulating ABCC2. Taken together, SNHG5 promotes imatinib resistance in CML via acting as a competing endogenous RNA against miR-205-5p.

Source: PubMed Central

Authors: Baoming He, Ying Bai, Wei Kang, Xiaoping Zhang, Xiaojian Jiang

Institutions: Hanzhong Central Hospital, Xian Central Hospital

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2981866206

FWCI: 4.717

Cites: 28

Cited by: 89

Related to: 10