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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

Year: 2020
Type: article
DOI: 10.1016/j.chembiol.2020.02.003
Authors: Sindhu Carmen Sivakumaren, Hyeseok Shim, Tinghu Zhang, Fleur M. Ferguson, Mark R. Lundquist, Christopher M. Browne, Hyuk-Soo Seo, Marcia N. Paddock, Theresa D. Manz, Baishan Jiang, Ming-Feng Hao, Pranav Krishnan, Diana G. Wang, T. Jonathan Yang, Nicholas P. Kwiatkowski, Scott B. Ficarro, James M. Cunningham, Jarrod A. Marto, Sirano Dhe-Paganon, Lewis C. Cantley, Nathanael S. Gray
Institutions: Harvard University, Dana-Farber Cancer Institute, NewYork–Presbyterian Hospital, Weill Cornell Medicine, Saarland University, Brigham and Women's Hospital, Whitehead Institute for Biomedical Research, Dana-Farber Brigham Cancer Center, Dana-Farber/Harvard Cancer Center
Language: English
Open Access status: bronze
Funders: Breast Cancer Research Foundation, Astellas Pharma US, Novartis, Sanofi, Takeda Pharmaceuticals U.S.A., Dana-Farber Cancer Institute, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases
Awards: Center on the Physics of Cancer Metabolism, Small molecule inhibitors of enveloped virus entry, Phosphoproteomic signatures for early detection and stratification of AML, G4637638745, G666778509, G6736130017, Development of covalent PIP4K2 inhibitors for the treatment of p53 deficient lung tumors, The Role of PI3K in Growth Regulation, Development of deep proteomic sequencing platforms for molecular markers in DLBCL, NE-CAT Center for Advanced Macromolecular Crystallography, G9000119994, G9000135115, G9000274384, Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism
OpenAlex ID: W3010473282
FWCI: 2.884
Cites: 67
Cited by: 56
Related to: 10