Year: 2019
Type: preprint
Abstract: MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage-specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development.
Source: Genome Research
Authors: Sorena Rahmanian, Rabi Murad, Alessandra Breschi, Weihua Zeng, Mark Mackiewicz, Brian Williams, Carrie Davis, Brian Roberts, Sarah Meadows, Dianna Moore, Diane Trout, Chris Zaleski, Alex Dobin, Lei-Hoon Sei, Jorg Drenkow, Alex Scavelli, Thomas Gingeras, Barbara Wold, Richard M. Myers, Roderic Guigó, Ali Mortazavi
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Awards: G2460856239, G3265251601, G9000031557
OpenAlex ID: W2982084458