Prenatal Phthalates Exposure and Childhood Adiposity, Adipokines, and Lipid Profiles at 48 and 72 months
Year: 2019
Type: article
Study design: Observational Study
Abstract: TPS 632: Health effects of flame retardants and plasticizers, Johan Friso Foyer, Floor 1, August 27, 2019, 3:00 PM - 4:30 PM Background/Aim: Prenatal phthalate exposure may impact child adiposity and cardiometabolic risk. However, periods of susceptibility and potential effects on lipid and adipokine profiles remain under explored. We examined associations of phthalate biomarkers at two time points during pregnancy with child adiposity, lipids and adipokines. Methods: We quantified 15 phthalate metabolites in 2nd and 3rd trimester maternal urine from 626 mother-child pairs in the PROGRESS Cohort of Mexico City. Body mass index (BMI) and percentage body fat (%BF) were assessed at 48 and 72 months. Fasting triglycerides, non-HDL cholesterol, leptin, and adiponectin were measured at 72 months. We generated phthalate biomarker molar sums of metabolites for each parent phthalate and of metabolites of high (ΣHMW) and low molecular weight (ΣLMW) phthalates. We estimated associations using linear mixed-effect models or linear regression then tested for effect modification by sex. Results: Select positive associations between 2nd trimester phthalates biomarkers sums and child adiposity at 48 and 72 months were observed, while other 2nd trimester phthalates biomarkers were inversely associated with lipids at 72 months. For instance, 2nd trimester ΣHMW phthalates were positively associated with child %BF, while 2nd trimester di-isodecyl phthalate metabolites (ΣDiDP) were inversely associated with BMI. ΣHMW phthalates in the 2nd trimester were inversely associated with non-HDL. 2nd trimester di(2-ethylhexyl) phthalate (ΣDEHP) and monoethyl phthalate were inversely associated with child triglycerides at 72 months. 2nd trimester ΣDEHP was positively associated with adiponectin, while 3rd trimester di-isononyl phthalate metabolites sum (ΣDiNP) was inversely associated with adiponectin. Sex-specific effects of ΣDiDP and select phthalates on all outcomes were observed. Conclusions: Pre-puberty, 2nd trimester phthalate exposure may be a critical window for childhood adiposity and cardiometabolic risk. Future research will employ mixture methods to examine potential interaction and cumulative effects of individual phthalates.
Source: Environmental Epidemiology
Authors: Kupsco A, Wu H, Calafat A, Tolentino M, Oken E, Braun J, Wright R, Téllez- Rojo M, Baccarelli A, Just A
Institutions: Columbia University, Centers for Disease Control and Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, National Institute of Public Health, National Institute of Public Health, National Institute of Public Health, National Institute of Public Health, National Institute of Public Health, Harvard University, Harvard Pilgrim Health Care, Brown University, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,200
OpenAlex ID: W2982132020