Response inhibition, white matter pathways and structural parcellation of the right inferior frontal gyrus
Year: 2019
Type: dissertation
Study design: Observational Study
Abstract: The right inferior frontal gyrus (rIFG) has been implicated in a range of cognitive functions, including response inhibition.However, a systematic investigation of its white matter pathways is still lacking.Here, diffusion weighted images (DWI) were acquired from 24 participants.Subsequently, 22 of the participants performed a delayed response task and a stop signal task (SST).An atlas-based deterministic tractography procedure was computed on the obtained DWIs.The rIFG was structurally parcellated into three sub-regions (i.e.pars opercularis, pars triangularis, pars orbitalis) and was subsequently inspected for white matter pathways to target regions involved in response inhibition.In addition, a segmentation of the pars opercularis into a dorsal and ventral region was conducted.Fractional anisotropy of the dorsal opercularis to pre-/supplementary motor area (preSMA/SMA) tract was positively associated with go reaction time obtained from the SST.Strikingly, the fractional anisotropy of the ventral opercularis-preSMA/SMA tract was negatively associated with go reaction time.Finally, the fractional anisotropy of the tract from the vOp to the insula were negatively associated with stop signal reaction time (SSRT), while mean diffusivity of the tract between orbitalis and subthalamic nucleus was positively associated with SSRT.VI VII
Author: Rune Bøen
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2982299073